Table 3.
Concentrations of pepsinogen I, pepsinogen II, and pepsinogen I to II ratio by histological categories1 in antrum and corpus in first-degree relatives of patients with gastric adenocarcinoma after successful H. pylori eradication (n = 115).
| Pepsinogen I (μg/mL) | Pepsinogen II (μg/mL) | Pepsinogen ratio | ||||||
|---|---|---|---|---|---|---|---|---|
| Median | IQR2 | Median | IQR | Median | IQR | |||
| Antrum | Neutrophil cell infiltration | High n = 1 | 32.5 | — | 13.5 | — | 2.4 | — |
| Low n = 114 | 77.3 | 59.0–103.5 | 7.1 | 5.3–9.5 | 11.3 | 7.9–14.9 | ||
| Mononuclear cell infiltration |
High n = 25 | 66.5 | 52.3–106.8 | 6.8 | 5.2–9.9 | 12.2 | 6.1–15.3 | |
| Low n = 90 | 80.0 | 59.4–103.5 | 7.2 | 5.3–9.7 | 10.7 | 8.0–14.9 | ||
| Atrophy | High n = 10 | 82.8 | 63.1–119.5 | 6.5 | 5.0–8.4 | 13.2 | 10.8–16.5 | |
| Low n = 105 | 77.1 | 57.6–103.0 | 7.2 | 5.4–9.7 | 10.7 | 7.9–14.5 | ||
| Intestinal metaplasia | High n = 10 | 66.4 | 58.5–91.3 | 5.4 | 4.9–10.3 | 13.1 | 10.6–14.4 | |
| Low n = 105 | 77.5 | 58.2–104.0 | 7.3 | 5.5–9.7 | 10.7 | 7.8–15.7 | ||
|
| ||||||||
| Corpus | Neutrophil cell infiltration |
High n = 0 | — | — | — | — | — | — |
| Low n = 115 | 77.1 | 58.7–103.1 | 7.1 | 5.3–9.6 | 11.2 | 7.9–14.8 | ||
| Mononuclear cell infiltration |
High n = 19 | 54.0∗ | 35.6–94.8 | 9.4 | 5.8–11.6 | 7.9∗∗ | 3.8–12.6 | |
| Low n = 96 | 80 | 60.5–104.4 | 6.9 | 5.1–9.0 | 11.6 | 8.4–15.6 | ||
| Atrophy | High n = 11 | 68.3 | 40.6–125.1 | 10.1∗ | 7.5–11.6 | 8.1 | 4.5–16.5 | |
| Low n = 104 | 80.0 | 59.4 | 6.9 | 5.1–9.0 | 11.3 | 8.2–14.6 | ||
| Intestinal metaplasia | High n = 8 | 38.1∗∗ | 25.8–93.5 | 7.8 | 4.7–12.8 | 4.1∗ | 2.5–15.0 | |
| Low n = 107 | 78.4 | 59.6–103.1 | 7.1 | 5.3–9.4 | 11.3 | 8.2–14.7 | ||
1Low score: normal or mild changes; high score: moderate or marked changes.
2IQR: interquartile range expressed as percentile 25–75.
∗ P < 0.05 & ∗∗P < 0.01 when pepsinogen concentrations (or pepsinogen ratio) were compared in groups of high and low histology scores (Mann-Whitney U test).