Table 4.

Concentrations of pepsinogen I, pepsinogen II, and pepsinogen I to II ratio according to histological categories¹ in antrum and corpus in first-degree relatives of patients with gastric adenocarcinoma in the control group & those with failed H. pylori eradication from the treatment group (n = 245).

			Pepsinogen I (μg/mL)		Pepsinogen II (μg/mL)		Pepsinogen ratio
			Median	IQR2	Median	IQR	Median	IQR
Antrum	Neutrophil cell infiltration	High n = 46	108.2	78.4–153.2	11.8	8.5–23.0	8.4	5.7–10.8
		Low n = 199	123.6	82.5–164.4	15.3	9.8–27.3	7.0	4.6–11.6
	Mononuclear cell infiltration	High n = 224	122.5	83.0–164.3	15.3∗	9.5–26.4	7.1	4.8–11.1
		Low n = 21	93.6	77.3–140.6	10.4	7.7–18.7	10.9	5.0–13.7
	Atrophy	High n = 58	126.9	88.0–166.5	14.8	8.1–26.3	8.2	5.0–12.5
		Low n = 187	120.9	81.7–160.7	15.2	9.7–26.3	7.0	4.8–10.9
	Intestinal metaplasia	High n = 29	119.5	69.1–175.7	16.0	11.0–28.6	5.1∗	4.0–8.6
		Low n = 216	122.2	82.6–161.5	14.9	9.0–25.7	7.6	5.0–11.7
Corpus	Neutrophil cell infiltration	High n = 38	149.0∗	105.9–192.4	24.4∗∗∗	11.4–41.2	5.2∗∗	3.7–9.0
		Low n = 207	118.2	81.3–157.4	14.7	8.9–23.9	7.6	5.1–11.8
	Mononuclear cell infiltration	High n = 172	123.2	82.2–164.3	18.1∗∗∗	10.4–27.8	6.7∗∗∗	4.3–10.1
		Low n = 73	109.1	82.1–159.0	11.5	7.9–19.3	9.9	5.9–12.5
	Atrophy	High n = 43	121.8	80.2–121.8	22.3∗	11.1–31.5	5.7∗	3.8–10.7
		Low n = 202	122.0	82.8–158.6	14.8	8.9–24.2	7.7	5.0–11.6
	Intestinal metaplasia	High n = 19	124.9	74.2–198.0	24.0	11.2–30.3	5.7∗	3.9–7.8
		Low n = 226	121.8	82.5–160.9	14.8	8.9–24.9	7.6	5.0–11.6

¹Low score: normal or mild changes; high score: moderate or marked changes.

²IQR: interquartile range expressed as percentile 25–75.

∗ P < 0.05, ∗∗P < 0.01, and ∗∗∗P < 0.001 when pepsinogen concentrations (or pepsinogen ratio) were compared in groups of high and low histology scores (Mann-Whitney U test).