Table 2.
Association of the 15 SNPs in INSIG-SCAP-SREBP pathway with obesity.
| Nearest gene | Effect allele | Obese vs nonobese | ||||
|---|---|---|---|---|---|---|
| OR | 95% CI | Nominal P valuea | ||||
| rs2721 | INSIG1 | T | 0.94 | 0.81 | 1.09 | 0.394 |
| rs13223383 | INSIG1 | T | 0.90 | 0.78 | 1.04 | 0.164 |
| rs7566605 | INSIG2 | C | 1.04 | 0.91 | 1.20 | 0.547 |
| rs10185316 | INSIG2 | G | 1.04 | 0.87 | 1.25 | 0.665 |
| rs13428113 | INSIG2 | C | 0.98 | 0.86 | 1.11 | 0.714 |
| rs17047757 | INSIG2 | G | 1.04 | 0.89 | 1.21 | 0.622 |
| rs9308762 | INSIG2 | T | 1.03 | 0.90 | 1.17 | 0.710 |
| rs12487736 | SCAP | G | 1.15 | 1.01 | 1.32 | 0.039 |
| rs12490383 | SCAP | C | 1.17 | 1.02 | 1.33 | 0.026 |
| rs2297508 | SREBP1 | C | 1.02 | 0.85 | 1.23 | 0.813 |
| rs60282872 | SREBP1 | DEL | 0.88 | 0.67 | 1.16 | 0.367 |
| rs7287010 | SREBP2 | T | 1.03 | 0.89 | 1.18 | 0.706 |
| rs1883205 | SREBP2 | T | 0.92 | 0.80 | 1.05 | 0.222 |
| rs133290 | SREBP2 | C | 0.98 | 0.85 | 1.14 | 0.825 |
| rs2228314 | SREBP2 | C | 1.17 | 1.00 | 1.37 | 0.051 |
aAdjusted for sex, age, age square, and study population.
INSIG1, insulin induced gene 1; INSIG2, insulin induced gene 2; SCAP, SREBP cleavage-activating protein gene; SREBP1, sterol regulatory element binding protein 1 gene; SREBP2, sterol regulatory element binding protein 2 gene.