Figure 3.

E-cadherin immunohistochemical expression in glomerulus and non-proximal tubules of a control kidney (A) and in glomerulus of a kidney with CGN (B); there is loss of E-cadherin expression in the nephritic glomerulus. (C), crescentic glomerulus with evidence for epithelial-to-mesenchymal (E-to-M) transformation of GEC identified by strong expression of α-smooth muscle actin in cells populating the crescent. Black arrows point to visceral and parietal GEC with E-to-M transformation, and to the vascular pole of the glomerulus. Scale bar: A and B, 100 µm; C, 50 µm.