Table 3.

Sexually dimorphic expression is detected within a diverse set of genes. Differentially transcribed genes between the genders that met the moderate statistical cutoff for significance were analyzed using Ingenuity pathway analysis bioinformatics database for shared ontological terminology. Sexually dimorphic gene expression was detected in a wide variety of molecular function, cellular location, and biological processes. The top five pathways are listed

Genes in network	Function
↑ACACA, AKR1B10, AKT1, ↑ALDH9Al, ARL4D, ↑C20ORF30, CASP3, ↓CFI, COL4A1, ↓COL7A1, ↓ COX4Il,FNl, ↑IFT20, INSIG1, LPIN1, NCSTN, ONECUT1, PPARG, PSENEN, PTPN12,↑RAPIA. RAPGEF5, ↓RBM5, RGS14, ↑RHEB, ↑RRAGD, SCD, ↓TGFB2, ↑TMBIM6, ↑TMED2, ↑TMEDIO, TNF, ↑TNFRSF19, TRAF6, UCP1	Connective Tissue Development and Function, Organismal Functions, Lipid Metabolism
ABCB7, ↑ALG2, APP, ↑CDK2AP1, CHRM4, COX5B, ↓EFHC2, ↑ERP29, EXOC8, ↑FECH, ↑GNB1,HGS, HTT, IL6, ↑LAMP2, MME.MYC, ↑MYOSB, MY05C, ↑NDUFA9, NDUFS3, NDUFV2, RTN2, ↑RTN4, RTN4R, SEC61A1, ↓SLIT2, ↓SV2B, TPD52, ↑TPD52Ll, UQCRC1, UQCRC2. VAMP4, VTI1B, XBP1	Neurological Disease, Organismal Injury and Abnormalities, Cellular Assembly and Organization
ABCF3, ACINI, ATF4, CDK5RAP3, CEBPA, CHMP1B, DISCI, ↓ERMP1, ↑FOXA1, G6PC, HNF4A. KLF5, MID1IP1, ↑MOCS2, ↑MRPS23, ↓NEK3, NR0B2, ONCUT1, PCK1, ↑PPC6C, PRLR, ↑PYCRl. RORA, RORC, ↓SFRS8,↑SNX3, SPP1, STAM, ↑STAMBP, TAGLN, TAT, ↑TMEM59, ↑TRMT12, UFC1, TTR	Carbohydrate Metabolism, Gene Expression, Amino Acid Metabolism
↑BTG1, ↑C220RF28, COL4A1, ↑COMMDIO, DNM1L, DTX3, DTX3L, ↑FUCA1, ↓GLS, GSK3B, HEX A, ↑HEXB, ↑HMBS, ↑PARK7, ↑PRUNE, RELA, RNF10, ↑RNF14, RNF114, RNF128, RNF166, RNF185, SUMOl, SYT1, ↓TLK2, TNF, TP53, TPD52, TRIM2, TRIM32, UBA2, ↑UBE2E1, ↑UBE2H. UBOX5, YWHAZ	Decreased Levels of Albumin, Antimicrobial Response, Lipid Metabolism
ANXA2, ATPA1A, CTNNB1, ↑CTNNBIPl, ↑DNAJA2, E2F2, E2F5, EDN1, ↑EFS, EGFR, EZH2. FAS, ↑HADH, KIT, KLF5, NCOR1, NDFIP1, NDFIP2, ↑PCBP2, ↑PDCD2, PHB2, ↑PHB, PIK3R1. PSEN1, ↓PTPRG, RBL2, ↓SEMA5A, ↑SETD8, ↑SLCHA2, ↑SLC5A1, SMARCA2, SPP1, TCF7L2, VDR, XPOl	Cell Cycle, Gene Expression, Cellular Growth and Proliferation

Genes in bold are those differentially expressed in the pathway, direction of arrow indicates up or down regulation.