Table 1. Systemic variables in various conditions of anesthesia and upstream blood supply.
| Experimental group | Brain blood supply | Anesthesia | n | MABP (mm Hg) | PaO2 (mm Hg) | PaCO2 (mm Hg) | pH |
|---|---|---|---|---|---|---|---|
| 1 | Normal | Isoflurane | 5 | 95.2±12.8 | 161.9±12.5 | 43.2±6.5 | 7.40±0.06 |
| Propofol | 5 | 106.3±19.0* | 152.4±18.3 | 54.1±6.1 | 7.33±0.03 | ||
| 2 | Normal | Isoflurane | 5 | 83.7±4.8 | 115.1±34.7 | 40.5±3.9 | 7.42±0.03 |
| Propofol | 4 | 96.3±10.4 | 141.7±42.2 | 49.0±3.2** | 7.33±0.03*** | ||
| 3 | Normal | Isoflurane | 5 | 82.0±15.7 | 153.0±22.5 | 46.3±6.6 | 7.41±0.05 |
| CCA1 | 5 | 86.1±13.5 | 142.2±20.9 | 47.9±6.4 | 7.40±0.05 | ||
| CCA2 | 4 | 85.1±22.8 | 146.0±20.0 | 42.0±3.6 | 7.40±0.07 | ||
| 4 | MCAo | Isoflurane | 2 | 97.0±21.5 | 142.6±71.5 | 42.3±3.6 | 7.41±0.06 |
| Propofol | 7 | 128.8±17.4 | 133.8±20.2 | 49.0±8.5 | 7.35±0.05 |
CCA, common carotid artery; MABP, mean arterial blood pressure; MCAo, middle cerebral artery occlusion.
Isoflurane was maintained at 1.5% to 2% and propofol was infused via tail vein at 38 mg/kg per hour. All values are given as mean±s.d. Arterial blood gas data are the average of the samples taken in each animal before each needle prick (groups 1 and 3) or before KCl application (group 2) or hourly (group 4). MMABP is the average over the full recordings in each condition. In all conditions, the systemic variables were within normal range. A paired t-test was performed between isoflurane and propofol in group 1, an unpaired t-test for groups 2 and 4, and a one-way repeated measures analysis of variance was performed in group 3 for factor ‘blood supply' (normal, unilateral CCA ligation or bilateral CCA ligation). *P<0.05, **P<0.01, ***P<0.005.