Table 1. Application of the graphical analysis to five SERT radioligands: [11C]McN5652, [11C]ADAM, [11C]DASB, [11C]DAPA, and [11C]AFM.
| x-Axis | y-Axis |
|||||||
|---|---|---|---|---|---|---|---|---|
| [11C]DASB |
[11C]DAPA |
[11C]McN5652 |
[11C]ADAM |
|||||
| Slope | y-Intercept | Slope | y-Intercept | Slope | y-Intercept | Slope | y-Intercept | |
| [11C]AFM | 0.43 (0.01) | 4.06 (0.87) | 0.58 (0.02) | 14.76 (1.33) | 0.38 (0.03) | 18.04 (1.95) | 0.37 (0.02) | 21.92 (1.44) |
| [11C]DASB | — | — | 1.33 (0.05) | 9.46 (1.59) | 0.88 (0.06) | 14.45 (1.90) | 0.86 (0.04) | 18.42 (1.30) |
| [11C]DAPA | — | — | — | — | 0.66 (0.04) | 8.22 (1.94) | 0.64 (0.02) | 12.36 (1.12) |
| [11C]McN5652 | — | — | — | — | — | — | 0.97 (0.05) | 4.78 (2.08) |
Linear regressions from paired VT comparisons of the radioligands are tabulated, s.e. in brackets. SERT, serotonin transporter; VT, total volume of distribution.