Figure 1.

Functional connectivity changes are displayed on cerebral surface maps and cerebellar flat maps. Increases are marked in hot colors and decreases are marked in cold colors (P<0.05, cluster corrected). (A) Significant differences in eigenvector centrality between the group of small vessel disease patients and healthy controls. Increases are found in cerebellar regions I to VI, whereas decreases are found in ventromedial prefrontal cortex (vmPFC), midcingulate cortex (MCC) and superior parietal lobe (SPL). (B) Regions with a significant correlation to the white matter lesion score. Positive correlations are found in the middle temporal sulcus (MTS), inferior temporal gyrus (ITG), cerebellar lobules Crus II, VIIb, and VIII; negative correlations are found in vmPFC, supplementary motor area (SMA), posterior cingulate cortex (PCC), and SPL.