Figure 8.

Hypothesis: The figure represents the proposed hypothesis for miR29b-induced mechanism in blood-barrier dysfunction. High levels of homocysteine in blood lead to increase in oxidative stress and miR29b that mediate the opening of blood–brain barrier (BBB) by directly targeting DNMT3b, which then target MMP9. The open BBB thereby influences permeability of the brain vessels and hence leads to BBB dysfunction. 5′-azacytidine improves blood–brain permeability by reducing miR29b and alleviating DNMT3b and MMP9 levels.