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Meta-analysis revealed significant reductions of 5-HTT in amygdala, but no effects in cortical regions. (A) A forest plot of molecular imaging studies of the amygdala in depressed patients, showing a significant reduction in 5-HTT levels. Forest plots for (B) frontal cortex and (C) cingulate cortex show no conclusive effect of major depression on 5-HTT availability. Δ5-HTT, mean difference in serotonin reuptake transporter level in units of s.d.
