Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Jun 23;5:4170. doi: 10.1038/ncomms5170

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2014, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

PMC Copyright notice

(a) Charged residues (red: positive-charged; blue: negative-charged) can reduce the site energy of CLA606 over 0.0035, eV individually. The tail of CLA606 is omitted in the figure for clarity. (b) Site energies of CLA606 on seven single mutations are shown. The collective mutations of all these seven residues dramatically increase CLA606’s site energy to almost the same value as its counterpart cofactor (CLA607) in the inactive chain. The wild-type site energies for both CLA606 and CLA607 are also displayed for reference. (c) These seven residues are highly conserved among different species. The sequence alignment was performed with the ClustalW2 program68,69.