Table 1.
Demographic and clinical characteristics of participants.
| Low vascular risk Mean (SD) | High vascular risk Mean (SD) | t or χ2 | P | |
|---|---|---|---|---|
| N | 55 | 16 | ||
| Age (years) | 74.73 (7.92) | 75.94 (7.35) | 0.55 | 0.59 |
| Education (years) | 16.31 (2.41) | 15.13 (2.03) | 1.79 | 0.08 |
| Women/men (% Women) | 33/22 (60.0%) | 8/8 (50.0%) | 0.51 | 0.48 |
| APOE ε4 carrier/non-carrier (% ε4 carrier)* | 16/37 (29.1%) | 9/7 (56.3%) | 3.61 | 0.06 |
| DRS total score | 139.82 (3.94) | 139.56 (4.50) | 0.22 | 0.83 |
| CVLT-II trials 1–5 total (T-score) | 46.43 (11.87) | 46.13 (11.74) | 0.43 | 0.67 |
| Trails B (s) | 80.57 (29.81) | 78.67 (34.19) | 0.21 | 0.83 |
| Geriatric depression scale | 3.40 (3.82) | 4.27 (3.54) | 0.79 | 0.43 |
| Systolic blood pressure | 129.16 (16.21) | 130.06 (12.45) | 0.21 | 0.84 |
| Diastolic blood pressure | 77.05 (9.30) | 71.31 (8.26) | 2.23 | 0.03 |
| Use of antihypertensive medications, n (%) | 23 (41.8%) | 14 (87.5%) | 10.39 | 0.006 |
| Hypertension, n (%) | 27 (49.1%) | 15 (93.8%) | 10.23 | 0.001 |
| Diabetes, n (%) | 1 (1.8%) | 4 (25%) | 10.18 | 0.001 |
| Cardiovascular disease, n (%) | 0 | 7 (43.8%) | 26.69 | <0.001 |
| History of atrial fibrillation, n (%) | 3 (5.5%) | 3 (18.8%) | 2.83 | 0.09 |
| Current smoker, n (%) | 2 (3.6%) | 0 | 0.60 | 0.44 |
| History of TIA or stroke, n (%) | 0 | 5 (31.3%) | 18.49 | <0.001 |
SD, standard deviation; APOE, apolipoprotein E; DRS, Mattis Dementia Rating Scale; CVLT-II, California Verbal Learning Test-Second Edition.
*
Two participants with low vascular risk factors burden were missing APOE genotype data.