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. Author manuscript; available in PMC: 2014 Dec 30.
Published in final edited form as: Nat Commun. 2014 Jun 30;5:4242. doi: 10.1038/ncomms5242

Figure 8.

Figure 8

Human C-peptide assay using 200-day-old human gut organoids and pancreatic islets. a, Human C-peptide release from gut organoids normalized by protein levels in organoid lysates. C: control adenovirus; D: HA-Δ256 FOXO1 adenovirus, B: basal glucose (2 mM); H: high glucose (22mM); A: arginine (10 mM); K: KCl (30 mM); ND: not detected. b, C-peptide secretion by human islets. Abbreviations are the same as in panel a. The numbers below the brackets refer to number of islets used. c, C-peptide content in gut organoids and human islets *p < 0.05 vs. organoids transduced with control virus (panel c) or basal vs. glucose- and arginine-stimulated conditions (panel b) (** p < 0.05 vs. human islets in panel c). We present data as means ± SEM (n = 3).

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