Malekzadeh 2010.

Methods	Block randomisation
Participants	475 participants (241 polypill; 234 control) without cardiovascular disease, hypertension, or hyperlipidaemia aged 50 to 79 years (men) and 55 to 79 years (women)
Interventions	Intervention: Polypill (aspirin 81 mg, enalapril 2.5 mg, atorvastatin 20 mg and hydrochlorothiazide 12.5 mg) Control: placebo
Outcomes	Hospital admissions / major cardiovascular events / seated and standing BP, LDL-C, total cholesterol, triglycerides, HDL-C and fasting glucose
Notes	Control: inactive/placebo
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Computer generated block randomisation
Allocation concealment (selection bias)	Low risk	Computer generation allocation to numbered list of blister packs manufactured by Alborz Darou
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Identical blister packs used for participant blinding
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Outcome assessors (clinicians) blinded to allocation
Incomplete outcome data (attrition bias) All outcomes	High risk	High rate of loss to follow-up at 12 months (experimental 32%; control 22%)
Selective reporting (reporting bias)	Low risk	Primary outcome reported (changes in blood pressure and LDL cholesterol)
Other bias	High risk	Run-in period excluded participants with low (<70%) adherence; large differences in baseline characteristics between intervention and control groups