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. Author manuscript; available in PMC: 2015 Apr 16.
Published in final edited form as: Cochrane Database Syst Rev. 2014 Apr 16;4:CD009868. doi: 10.1002/14651858.CD009868.pub2

Table 1. Polypill content by trial.

Study Polypill contents (dose) Comparator
CRUCIAL 2011 Amlodipine 5 to 10 mg Usual care
Atorvastatin 10mg1
CUSP 2009 Amlodipine 5 mg Placebo
Atorvastatin 20 mg
Malekzadeh 2010 Aspirin 81 mg Placebo
Atorvastatin 20 mg
Enalapril 2.5 mg
Hydrochlorothiazide 12.5 mg
PILL 2011 Aspirin 75 mg Placebo
Hydrochlorothiazide 12.5 mg
Lisinopril 10 mg
Simvastatin 20 mg
Soliman 2009 Aspirin 75 mg Usual care
Hydrochlorothiazide 12.5 mg
Lisinopril 10 mg
Simvastatin 20 mg
TIPS 2009 Aspirin 100 mg 8 other drug/drug combination groups:

  1. Aspirin 100mg

  2. Aspirin 100mg, hydrochlorothiazide 12.5mg, atenolol 50mg, ramipril 5mg

  3. Hydrochlorothiazide 12.5mg

  4. Hydrochlorothiazide 12.5mg, atenolol 50mg

  5. Hydrochlorothiazide 12.5mg, ramipril 5mg

  6. Hydrochlorothiazide 12.5mg, atenolol 50mg, ramipril 5mg

  7. Ramipril 5mg, atenolol 50mg

  8. Simvastatin 20mg
Atenolol 50 mg
Hydrochlorothiazide 12.5 mg
Ramipril 5 mg
Simvastatin 20 mg
TOGETHER 2010 Amlodipine 5 to 10 mg Amlodipine 5 to 10 mg
Atorvastatin 10mg
UMPIRE 2013 Aspirin 75mg Usual care
Atenolol 50mg
Lisinopril 40mg
Simvastatin 40mg
or
Aspirin 75mg
Hydrochlorothiazide 12.5mg
Lisinopril 40mg
Simvastatin 40mg
Wald 2012 Amlodipine 2.5 mg Placebo
Hydrochlorothiazide 12.5 mg
Losartan 25 mg
Simvastatin 40mg
1

Site investigators could request dosages of amlodipine and atorvastatin 5/20 mg and 10/20 mg