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. Author manuscript; available in PMC: 2014 Jul 7.
Published in final edited form as: Curr Opin Struct Biol. 2012 Nov 8;22(6):701–710. doi: 10.1016/j.sbi.2012.10.005

Figure 3.

Figure 3

Representative radical SAM reactions. (a) BioB catalyzes the sequential abstraction of hydrogen atoms from C9 and C6 of DTB (left), with insertion of sulfur from the [2Fe–2S] cluster. (b) AlbA incorporates three thioether bonds between three cysteines and the α-C of two phenylalanines and one threonine during the maturation of subtilosin A. Shown is a representative reaction between one cysteine and threonine. (c) NosL and NocL catalyze a fragmentation–recombination reaction of l-Trp to MIA which is incorporated into NOS in the case of NosL or NOC-I in the case of NocL. (d) RlmN and Cfr catalyze the methylation of A2503 of the 23S rRNA utilizing two equivalents of SAM. The sequential methylations catalyzed by these two enzymes can occur in either order.