Table 2.
Expression profiles |
Primary screen* without Doxo |
Primary screen with Doxo |
Secondary screen | |||||||
---|---|---|---|---|---|---|---|---|---|---|
Gene | ChIP-on-CHIP | ASPS | Inducible 293 | Stockwin [28] | Apoptosis | Decrease in cell number | Apoptosis | Decrease in cell number | Decrease in cell number | |
1 | ANGPTL2 | + | + | + | + | + | - | + | - | + |
2 | LGALS3BP | + | + | - | + | + | - | + | + | + |
3 | MET | + | + | + | + | + | + | + | + | + |
4 | NAMPT | + | - | + | + | + | - | + | + | + |
5 | PCGF1 | + | - | + | - | - | - | - | + | + |
6 | PRICKLE3 | + | -** | + | - | + | - | + | + | + |
7 | PTPRF | + | - | + | - | - | + | + | + | + |
8 | SLC29A1 | + | + | - | + | + | - | + | + | + |
9 | SOCS3 | + | - | + | - | + | - | - | + | + |
10 | SV2B | + | + | + | + | - | - | + | + | + |
11 | 7YRO3 | + | - | + | - | - | - | + | + | + |
12 | UPP1 | + | + | + | + | - | - | - | + | + |
Numbers refer to quantity of siRNAs/gene that resulted in a changed phenotype.
This gene was not on the Affymetrix U133A array.