Table 2.

Up-regulated direct targets of ASPSCR1 –TFE3 confirmed to contribute to proliferation and survival of ASPSCR1 –TFE3-positive cells (see text for details)

			Expression profiles			Primary screen* without Doxo		Primary screen with Doxo		Secondary screen
	Gene	ChIP-on-CHIP	ASPS	Inducible 293	Stockwin [28]	Apoptosis	Decrease in cell number	Apoptosis	Decrease in cell number	Decrease in cell number
1	ANGPTL2	+	+	+	+	+	-	+	-	+
2	LGALS3BP	+	+	-	+	+	-	+	+	+
3	MET	+	+	+	+	+	+	+	+	+
4	NAMPT	+	-	+	+	+	-	+	+	+
5	PCGF1	+	-	+	-	-	-	-	+	+
6	PRICKLE3	+	-**	+	-	+	-	+	+	+
7	PTPRF	+	-	+	-	-	+	+	+	+
8	SLC29A1	+	+	-	+	+	-	+	+	+
9	SOCS3	+	-	+	-	+	-	-	+	+
10	SV2B	+	+	+	+	-	-	+	+	+
11	7YRO3	+	-	+	-	-	-	+	+	+
12	UPP1	+	+	+	+	-	-	-	+	+

^*Numbers refer to quantity of siRNAs/gene that resulted in a changed phenotype.

^**This gene was not on the Affymetrix U133A array.