Table 6.

Performance of different machine learning methods, evaluated by LOOCV.

Method	Bound dataset					Unbound dataset
	F	ACC	SN	SP	AUC	F	ACC	SN	SP	AUC
ANN	0.294	0.723	0.629	0.732	0.643	0.276	0.678	0.659	0.679	0.645
KNN	0.323	0.744	0.666	0.752	0.654	0.298	0.692	0.662	0.665	0.648
SVM	0.330	0.750	0.648	0.760	0.661	0.312	0.689	0.704	0.687	0.652