Table 2.
Multivariable analysis of the hazard associated with traditional risk factors and kidney function for study outcomes. Data are displayed as hazard ratio (95% confidence interval).
| Cardiac | Stroke | Mortality | Composite | |
|---|---|---|---|---|
| Demographics | ||||
| Age | 1.68 (1.39, 2.02) | 1.49 (1.18, 1.89) | 2.20 (1.93, 2.51) | 1.84 (1.63, 2.08) |
| Female | 0.49 (0.38, 0.63) | 0.67 (0.49, 0.92) | 0.57 (0.48, 0.67) | 0.57 (0.49, 0.67) |
| African American Race | 1.26 (0.93, 1.72) | 0.95 (0.62, 1.43) | 1.20 (0.96, 1.51) | 1.25 (1.02, 1.53) |
| Study: ARIC | 1.62 (1.07, 2.47) | 0.98 (0.56, 1.73) | 1.83 (1.33, 2.52) | 1.41 (1.07, 1.87) |
| Medical History | ||||
| Cardiovascular Disease | 2.32 (1.86, 2.89) | 1.85 (1.40, 2.45) | 1.60 (1.37, 1.87) | 1.74 (1.51, 2.01) |
| Diabetes | 1.86 (1.44, 2.40) | 1.89 (1.34, 2.66) | 2.02 (1.67, 2.44) | 1.73 (1.45, 2.07) |
| Current Smoking | 1.30 (0.94, 1.79) | 1.30 (0.85, 1.97) | 1.67 (1.34, 2.09) | 1.63 (1.33, 1.99) |
| Exam and Laboratory | ||||
| Systolic Blood Pressure | 1.13 (1.03, 1.23) | 1.30 (1.16, 1.45) | 1.09 (1.02, 1.16) | 1.11 (1.05, 1.18) |
| LVH | 1.57 (1.11, 2.23) | 1.72 (1.13, 2.63) | 1.70 (1.32, 2.18) | 1.45 (1.15, 1.85) |
| Total Cholesterol | 1.03 (0.98, 1.08) | 1.03 (0.97, 1.10) | 0.99 (0.95, 1.03) | 1.02 (0.98, 1.05) |
| HDL Cholesterol | 0.98 (0.90, 1.07) | 1.04 (0.94, 1.15) | 1.05 (0.99, 1.11) | 1.03 (0.97, 1.08) |
| GFR | 0.91 (0.86, 0.97) | 0.90 (0.84, 0.97) | 0.86 (0.83, 0.90) | 0.87 (0.84, 0.91) |
Age is assessed per 10-year increase; systolic blood pressure per 20 mm Hg increase; total cholesterol per 20 mg/dL (0.52 mmol/L) increase; high density lipoprotein (HDL) cholesterol per 10 mg/dL (0.26 mmol/L) increase; and glomerular filtration rate (GFR) per 5 mL/min/1.732 (0.08 mL/sec/1.73m2) increase. LVH, left ventricular hypertrophy diagnosed by electrocardiogram characteristics.