Table 2.

Cairo-Bishop grading of clinical tumor lysis syndrome for adults.

Variable	Grade 0	Grade I	Grade II	Grade III	Grade IV	Grade V
Creatinine	None	1.5 times ULN	>1.5-3.0 times ULN	>3.0-6.0 times ULN	>6.0 times ULN	Death
Cardiac arrhythmia	None	Intervention not indicated	Non-urgent medical intervention indicated	Symptomatic and incompletely controlled medically or controlled with device (e.g., defibrillator)	Life-threatening (e.g., arrhythmia associated with heart failure, hypotension, syncope, shock)	Death
Seizures	None	-	One brief, generalized seizure; seizure(s) well controlled by anticonvulsants or focal motor seizures not interfering with ADL	Seizure in which consciousness is altered; poorly controlled seizure disorder; with breakthrough generalized seizures despite medical intervention	Seizure of any kind which are prolonged, repetitive or difficult to control (e.g., status epilepticus, intractable epilepsy)	Death

ULN, upper limits of normal; ADL, activities of daily living.