Figure 5.

Effects of CDX-4MDM treatment on the levels of LTB₄, PGP, and neutrophils in mice exposed to cigarette smoke for 20 weeks. Panel A: In silico modeling of the LTA₄H binding pocket occupied by 4MDM and PGP overlaid with the predicted binding model of the LTA₄. 4MDM = orange. PGP = yellow. LTA₄ = purple. Panel B: Levels of LTB₄ in BALF with oral CDX-4MDM or vehicle treatment post exposure to cigarette smoke for 20 weeks. Panel C: Levels of PGP in BALF with oral CDX-4MDM or vehicle treatment post exposure to cigarette smoke for 20 weeks. Panel D: Levels of CD45⁺CD11b⁺Ly6G⁺ cells in whole lung single cell suspension with oral CDX-4MDM or vehicle treatment post exposure to cigarette smoke for 20 weeks. Panel E: Levels of CD45⁺CD11b⁺Ly6G⁺ cells in whole lung single cell suspension of 129sv WT mice (black bars) and 129sv mice with null mutation at the LTA₄H loci (gray bars) with oral CDX-4MDM or vehicle treatment post exposure to cigarette smoke for 7 days. * represents analysis by ANOVA, ** by Bonferroni subgroup comparison, and *** by nonparametric t-Test. N = 5 – 6 per group.