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Lipoprotein profiles in apo E–deficient mice are not altered by 12/15-lipoxygenase deficiency. Representative plasma lipoprotein profiles of apo E–/–/L-12LO–/– double-knockout mice and apo E–/–/L-12LO+/– control mice. Pooled plasmas from two or three 15-week-old mice on chow diet (n = 2–4) were fractionated by FPLC, using 2 Superose 6 columns in series. Fractions were then assayed for cholesterol in duplicates. All values are expressed as micrograms per fraction per 100 μL of plasma.
