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The ability of 12/15-lipoxygenase–deficient macrophages to synthesize the arachidonate metabolites 12-HETE/15-HETE is abolished. Profiles of monohydroxy arachidonic acid metabolites synthesized by apo E–/–/L-12LO+/+ macrophages (left), apo E–/–/L-12LO+/– macrophages (middle), and apo E–/–/L-12LO–/– macrophages (right) incubated with arachidonic acid and analyzed by RP-HPLC. 12-HETE production in the left panel was 0.63 nmol/106 cells.
