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. 1999 Jun 1;103(11):1597–1604. doi: 10.1172/JCI5897

Figure 5.

Figure 5

12/15-lipoxygenase deficiency delays progression of lesion development in apo E–deficient mice. (a) Representative Sudan IV–stained aortas of an apo E–/–/L-12LO–/– double-knockout mouse (left) and an apo E knockout mouse heterozygous for L-12LO (right). Mice were raised on a normal chow diet and sacrificed at 1 year of age (n = 12 and n = 10, respectively). Atheromatous plaques are at a much more advanced stage in the apo E–/–/L-12LO+/– group and include large parts of the thoracic and abdominal aorta, with near occlusion in the renal artery area. (b) Atherosclerotic average lesion area in en face preparations at 1 year of age. Values are mean ± SEM. **P < 0.0001 (Mann-Whitney test).