Effect of G6P and high glucose concentration on NADPH production by intact adrenal microsomes. Isolated intact adrenal microsomes were incubated according to the methods for 15 min as follows: no additions (control), 1 mM NADP, 1 mM G6P, 1 mM NADP + 1 mM G6P, 1 mM NADP + 600 mM glucose, 1 mM NADP + 1 mM F6P, 1 mM NADP + 6.6 mM GlcN6P. Results are given as a mean ± SD, n = 3. Statistical differences were by unpaired t test (NADP versus NADP + G6P or versus NADP + glucose or NADP + F6P or NADP + GlcN6P were all p < .001). There was no statistical difference between the control, NADP or G6P alone groups.