Figure 4.

Distribution of junctional conductance values evaluated in CFPAC-1 and PLJ-CFTR cell pairs monitored under dual patch-clamp, with intracellular solutions supplemented or not with 20–100 μM S_p-cAMPS. As shown, S_p-cAMPS did not affect junctional conductance of CFPAC-1 cells. In contrast, junctional conductance values of PLJ-CFTR cells, which are lower than those measured in parental cells, are markedly increased (P < 0.05) in the presence of S_p-cAMPS in intracellular solutions. Bars represent the median values of junctional conductance.