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. Author manuscript; available in PMC: 2015 Jun 15.
Published in final edited form as: Cancer Res. 2014 Apr 16;74(12):3369–3377. doi: 10.1158/0008-5472.CAN-13-3216

Figure 6. E2f1S29A/S29A mice have increased sensitivity to UV-induced skin carcinogenesis.

Figure 6

(a) The dorsal skin of 4-5 weeks old E2f1S29A/S29A (N=21) and wild type sibling control (N=22) mice were shaved and exposed to 337 J/m2 of UVB three times per week for 48 weeks. A statistically significant difference in skin tumor incidence over time was observed using the log-rank Mantel-Cox test (p = 0.0012). (b) Young adult wild type (E2f1+/+) and E2f1S29A/S29A mice were exposed to 337 J/m2 UVB three times per week as above for 5 weeks. 24 h after the last treatment skin samples were taken and immunohistochemically stained for p53. The average number of positive cells per mm2 of epidermis is presented from 3 mice per genotype. Bars represent standard deviation and * indicates statistical significance using two sample independent t test (p = 0.0026).