Figure 1.

Representative examples of BAL fluid cells isolated from PBS-treated HLA-DQ or H-2Aβ⁰ mice (a), SRW-sensitized and -challenged H-2Aβ⁰ (b) and HLA-DQ6 (c) mice, and anti-DQ–treated SRW-immunized HLA-DQ6 mice (d) 48 hours after intranasal challenge with allergenic extract. No eosinophils were recovered in BAL from any groups of PBS-treated mice (a) or SRW-sensitized and -challenged MHC class II knockout mice (b). Eosinophils were found to dominate the cellular infiltrate into BAL of HLA-DQ6 and HLA-DQ8 transgenic mice (c). Only a few eosinophils can be seen in anti-DQ–treated SRW-immunized mice (d). e, eosinophils; l, lymphocytes; m, macrophages.