Figure 4.

Histopathology of lung tissue from PBS (a) and SRW-sensitized and -challenged (b–e) mice. Tissue section were prepared as described in Methods and were stained with hematoxylin and eosin. The photomicrograph in a shows that there is no inflammation in lung tissue from PBS-treated mice (×10). This is contrasted with multiple sites of inflammation in tissue taken 48 hours after allergen challenge of SRW-sensitized HLA-DQ6 (b) transgenic mice (×10). (c and d) Lung sections of an HLA-DQ6 mouse treated with SRW show a diffuse eosinophilic infiltration around and in the bronchioli, with involvement of the bronchiolar epithelium and associated epithelial damage. (e) Reduction in peribronchial and perivascular inflammation in HLA-DQ6 mice after treatment with anti-DQ mAb.