Figure 6.

Immunohistochemical localization of HLA-DQ molecules in lungs, as detected by the brown avidin-biotin peroxidase reaction product. Representative areas of the airway tissue from PBS-treated HLA-DQ6 mice revealed transgene expression on epithelium and endothelium (a), which was not observed in the lungs of transgene-negative H-2Aβ⁰ mice (b). (c) SRW sensitization and challenge of HLA-DQ mice markedly reduce the antigen expression and lead to the prominent infiltration with cells not having HLA-DQ marker on their surface. (d) Anti-DQ treatment reconstitutes transgene expression in allergen-sensitized HLA-DQ6 mice.