Figure 8.

Assessment of lung physiology. Airway responsiveness in SRW-sensitized H-2Aβ⁰ mice (a) and transgenic mice expressing HLA-DQ6 (b) or HLA-DQ8 (c) molecules was measured 48 hours after intranasal challenge with SRW (filled squares). Control mice (open circles) were treated with PBS as described in Methods. Results are expressed for each methacholine concentration as percent of PenH (index of airway obstruction) values after PBS exposure (n = 3 for each experimental group). *P < 0.04 SRW sensitized/challenged vs. PBS sensitized/challenged HLA-DQ mice.