Table 2.
Traditional outcome markers and CMR parameters: association with MACE in univariable and stepwise multivariable Cox regression analysis
| |
Univariable analysis |
Multivariable analysis |
||
|---|---|---|---|---|
| Variable | HR (95% CI) | P value | HR (95% CI) | P value |
| Male gender |
0.97 (0.53–1.77) |
0.97 |
not included |
- |
| Hyperlipidemia |
1.42 (0.82–2.47) |
0.21 |
not included |
- |
| Serum creatinine, μmol/l |
1.01 (0.99–1.02) |
0.23 |
not included |
- |
| CK-MBmax, μmol/l |
1.02 (1.01–1.03) |
0.01 |
- |
- |
| TIMI-risk score |
1.27 (1.15–1.41) |
<0.001 |
- |
- |
| ST-segment resolution, % |
0.98 (0.97–0.99) |
0.001 |
- |
- |
| TIMI-flow pre-PCI 0 |
1.24 (1.01–1.53) |
0.04 |
- |
- |
| TIMI-flow post-PCI 0-II |
2.49 (1.44–4.31) |
0.001 |
- |
- |
| LV-EFecho, % |
0.95 (0.92–0.97) |
<0.001 |
- |
- |
| Time-to-revascularization, min |
1.00 (0.99–1.01) |
0.44 |
not included |
- |
| LV-EFCMR, % |
0.96 (0.94–0.97) |
<0.001 |
- |
- |
| Infarct size, %LV |
1.07 (1.05–1.09) |
<0.001 |
- |
- |
| MO, %LV |
1.16 (1.07–1.25) |
<0.001 |
- |
- |
| MSI | 0.93 (0.92–0.95) | <0.001 | 0.94 (0.92–0.96) | <0.001 |
%LV = percentage of left ventricular mass; CK-MBmax = maximum level of creatine kinase-MB; CI = confidence interval; CMR = cardiac magnetic resonance imaging; HR = hazard ratio; LV-EFCMR = left ventricular ejection fraction assessed by CMR; LV-EFecho = left ventricular ejection fraction assessed by echocardiography; MACE = major adverse cardiac events; MO = microvascular obstruction; MSI = myocardial salvage index; PCI = percutaneous coronary intervention; TIMI = Thrombolysis In Myocardial Infarction.