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. 1999 Aug 1;104(3):229–237. doi: 10.1172/JCI5705

Figure 1.

Figure 1

In vivo findings of the tibiae of wild-type, klotho (kl/kl), and rescued klotho (kl/kl, tg/+) mice. (a) BMD of the whole tibiae at 3, 5, and 7 weeks of age. *Significantly different from wild-type mice (P < 0.01). Data are expressed as mean (symbols) ± SEM (error bars) for 8 bones per group for wild-type and kl/kl, and 5 bones for kl/kl, tg/+. (b) BMD of each of 20 equal longitudinal divisions of tibiae from 7-week-old mice. (c) Histological features of the proximal metaphysis and the diaphysis of the tibiae of 7-week-old wild-type and kl/kl mice. Mineralized bone is stained green and unmineralized osteoid stained red by the Villanueva-Goldner method. Original magnification: ×20. Histomorphometric parameters are shown in Table 1.