Skip to main content
. 1999 Aug 1;104(3):281–290. doi: 10.1172/JCI6656

Figure 7.

Figure 7

Permanent acceptance of GalT+/+ donor-type hearts in GalT+/+→GalT–/– mixed chimeras. The hearts from donor-type GalT+/+ (H-2bxd) mice were heterotopically transplanted into mixed chimeras (n = 6; including 2 chimeras transplanted with 20 × 106, 7.5 × 106, or 1 × 106 GalT+/+ BMCs) 19–20 weeks after BMT, as well as into conditioned control GalT–/– (H-2d) (n = 6) and GalT+/+ mice (H-2d) (n = 5) and untreated control GalT–/– mice (H-2d) (n = 4). As an H-2–identical control, hearts from GalT+/+ (H-2d) mice were transplanted into GalT+/+ (H-2d) mice (n = 3). To enhance anti-Gal NAb production, all recipient animals were immunized by intraperitoneal injection of 1 × 109 rabbit erythrocytes 8 or 9 days before heart transplantation. Survival curves of the grafted hearts are shown. P < 0.005 normal GalT–/–, conditioned GalT–/–, or conditioned GalT+/+ vs. mixed chimeras. P < 0.005 normal GalT–/– or conditioned GalT–/– vs. conditioned GalT+/+.