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IL-2 production by anti-DNA autoantibody–inducing T-cell clone DD2 in response to nucleosomal histone peptides (10 μM each) presented by autologous EBV B-cell APCs. Bars represent mean of triplicate values. Values higher than 3 SD (horizontal line) above the mean of background (DD2 + APCs without added peptide produced 132 pg/mL IL-2) were considered as stimulatory. IL-2 production by DD2 in response to anti-CD3 stimulation was 554 pg/mL.
