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. 1999 Aug 1;104(3):345–355. doi: 10.1172/JCI6801

Figure 2.

Figure 2

(a) IL-2 production by a representative short-term CD4 T-cell line L-EB, with different concentrations of histone H449–63 peptide-pulsed autologous EBV B-cell APCs. Stimulation with 0.01–100 μM peptide showed significant differences (*P < 0.05 at 0.01 μM, Student’s t test) from background (T cells plus APCs cultured without peptide). (b) An example of MHC class II–dependent recognition of nucleosomal peptides. Presentation of H449–63 peptide by autologous EBV B cells to short-term T-cell line L-EB was inhibited mainly by anti-DR mAb.