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Growth of xenograft tumors. (a) Animals with 1 tumor of each genotype were treated with either 7.5 Gy or 15 Gy doses of γ-radiation. (b) Intravenous 5-FU (12.5 mg/kg) or carrier alone (No drug) was administered on 2 consecutive days, ending on day 0. Filled triangles: tumors composed of p53++-containing cells; open triangles: tumors composed of p53–/– cells.
