Figure 3.

Topical application of LXA₄ inhibits PMN infiltration in hBLTR TG mice. The LXA₄ stable analogue (10 μg, 26 nmol) 16-phenoxy-LXA₄ (inset: LXA₄ analogue template R₂= phenoxy) was applied topically to right ears of nTG and hBLTR TG mice (hatched bars). Left ears received vehicle alone (filled bars). LTB₄ (1 μg) was then applied to both ears of each mouse 5 minutes later. Skin biopsies were obtained as just described. Values represent total PMN infiltration into ear skin (representative data from 3 experiments).