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Time- and dose-dependent increase in excretion of iPF2α-III in healthy volunteers administered alcohol. Acute oral doses (240 mL) of alcohol or a control solution were administered under randomized, double-blind, controlled conditions. Urinary iPF2α-III increased significantly (P < 0.001) as a function of dose. Alcohol also increased urinary iPF2α-III in a time-dependent manner, with the 3 highest dose groups (P < 0.01) peaking in the fraction collected 0–6 hours after dosing.
