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. 1999 Sep 15;104(6):697–708. doi: 10.1172/JCI6837

Figure 5.

Figure 5

Effects of CGM3-5 mAb’s on spontaneous quantal transmitter release at the mouse NMJ. (a) MEPP frequencies were measured in left diaphragm muscle-nerve preparations that were incubated with either CGM3 (48 μg/mL), CGM4 (67 μg/mL), CGM5 (29–39 μg/mL), or control IgM (67 μg/mL) (open bars) and then with normal human serum as a source of complement (filled bars). In contralateral right hemidiaphragms, control MEPP frequencies were measured in Ringer’s medium (shaded bars). Mean values ± SEM (n = 2 muscles; 7–15 NMJs sampled per muscle). (b) Typical examples of 1-second traces recorded in an untreated preparation and in CGM5-pretreated preparations with or without the addition of normal human serum as a source of complement.