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Serum bone specific alkaline phosphatase, osteocalcin, collagen propeptide of type I collagen (PICP), and urinary type I C-telopeptide breakdown products (CrossLaps) versus estradiol. Numbers denote maturational stages; 1 (Tanner stage 1), 2 (includes Tanner stages 2–4), 3 (1.0 ± 0.1 years after menarche), and 4 (3.7 ± 0.1 years after menarche).
