Figure 1.

Changes in insulin action (top 2 rows), insulin secretion (third row), and EGO (bottom row) in 17 Pima Indian subjects in whom glucose tolerance deteriorated from normal (NGT) to impaired (IGT) to diabetic (DIA) over 5.1 ± 1.4 years (progressors, left), compared with changes in 31 Pima Indian subjects who retained NGT over a comparable interval (4.8 ± 2.3 years) (nonprogressors, right). The AIR was measured in 11 and 23 subjects, respectively. Group results are given as columns (mean ± SEM); individual results are given in the insets at the upper right corners. Asterisks indicate significant differences between the 3 stages within each group (*P < 0.05, **P < 0.01). The results of the between-group comparison are given in the center tables.