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Generation of mice with a targeted, disrupted Tsc2 allele. (a) Genomic structure and creation of a targeting construct for the Tsc2 gene. E, EcoRI; B, BamHI; P, PstI. (b) Southern blot analysis of BamHI-digested ES cell DNA, demonstrating disruption of the Tsc2 gene in 2 of 4 clones: T19 and T27. (c) PCR genotyping of the induced mutation in the Tsc2 gene.
