Table 1.

Summary of dopamine pathway genes and parameter estimates

						Belief learning (δ)				Learning rate (ρ)
Function	Gene	SNPs	PCs	% Var	k*	LLR	punc	pperm	pemp	LLR	punc	pperm	pemp
Synthesis	TH	2	2	100	1,089	0.98	0.374	0.898	0.888	0.9	0.400	0.913	0.932
	DDC	20	4	90	162	3.45	0.141	0.943	0.963	29.3	0.000	0.257	0.278
	VMAT2	16	8	92	22	31.1	0.000	0.420	0.410	12.3	0.002	0.969	1.000
Transport/clearance	DAT1	9	5	93	73	9.35	0.002	0.821	0.808	68.6	0.000	0.024	0.027
	VNTR					0.22	0.510	0.796		34.5	0.000	0.008
	Joint					9.7	0.007	0.877		86.9	0.000	0.014
	COMT	17	4	91	191	57.3	0.000	0.005	0.005	49.8	0.000	0.038	0.031
	MAOA	22	1	94	4	12.3	0.000	0.082	0.25	0.2	0.495	0.834	1.000
	VNTR					3.5	0.136	0.687		17.4	0.000	0.498
	Joint					32.1	0.000	0.029		32.7	0.000	0.691
	MAOB	28	3	95	70	32.7	0.000	0.035	0.029	1.2	0.000	0.585	0.586
Receptor	DRD1	5	3	99	275	9.22	0.000	0.522	0.510	9.76	0.000	0.639	0.647
	DRD2	17	5	94	159	24.8	0.000	0.295	0.296	67.5	0.000	0.036	0.025
	DRD3	6	3	97	289	2.49	0.174	0.881	0.917	23.9	0.000	0.219	0.201
	DRD4	1	1	100	975	3.40	0.009	0.335	0.396	9.46	0.000	0.193	0.183
	VNTR					11.9	0.000	0.247		12.5	0.000	0.314
	Joint					12.0	0.000	0.398		25.8	0.000	0.207

PCs, principal components; % Var, percent of total variance captured by included PCs; p_unc, P value using likelihood ratio test; p_perm, permutation P value (see SI Materials and Methods); p_emp, empirical P value (see SI Materials and Methods); TH, tyrosine hydroxylase; VMAT2, vesicular monoamine transporter 2.

^*Number of matched comparison genes chosen from the GWA dataset.