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. 2014 Jun 16;111(26):9579–9584. doi: 10.1073/pnas.1323493111

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Fig. 1. — Treg frequencies in Klf2 gene-targeted mice. (A) Percent FoxP3⁺CD25⁺ Tregs relative to CD4⁺ T cells in tissues harvested from Klf2^fl/fl (control) vs. Lck-cre; Klf2^fl/fl (cKO) littermates (6 wk of age). This experiment was repeated four times. Ms LN, mesenteric lymph nodes; Ax LN, axillary lymph nodes. (B) Percent Tregs relative to CD4⁺ thymocytes in 3-wk-old Klf2^fl/fl (control) or Lck-cre; Klf2^fl/fl (cKO) littermates. This experiment was performed three times. (C) Proportion of Tregs present in Klf2^fl/fl (control), Vav-cre; S1P₁^fl/fl (S1P₁ cKO), Vav-cre; Klf2^fl/fl (Klf2 cKO), and Vav-cre; S1P₁^fl/fl; Klf2^fl/fl (dKO) littermates (n = 2 mice per group). FACS plots: flow cytometric analysis of CD4⁺ T cells in the spleen. % FoxP3⁺CD25⁺ Tregs are indicated. Bar graph: average frequency of Tregs relative to CD4⁺ T cells in lymphoid organs. Mice were 7 wk old. This experiment was repeated twice (excluding S1P₁ cKO littermates, which were analyzed once).