Fig. 4.

Comparison of Aβ40 and Aβ42 aggregation data. Comparison of the experimental kinetic datapoints of Aβ40 (red) and Aβ42 (blue) at a monomer concentration of 3.5 μM. The times for each dataset are rescaled by the corresponding half-times and the steeper increase of the Aβ40 curve is indicative of its stronger autocatalytic behavior, on a relative scale. The solid lines (Aβ40 in red and Aβ42 in blue) are a prediction for the same system in the absence of secondary nucleation but with all of the other rate constants at the values determined from the experiment. The significant difference in these predictions highlights the larger relative contribution of secondary nucleation for Aβ40 relative to Aβ42.