Fig. 8.
Schematic diagram of a proposed mechanism showing how Ninj1 blockade restores erectile function in diabetic mice. Ang1, angiopoietin1; Ang2, angiopoietin-2; BDNF, brain-derived neurotrophic factor; EC, endothelial cell; eNOS, endothelial nitric oxide synthase; iNOS, inducible nitric oxide synthase; NGF, nerve growth factor; Ninj1, nerve injury-induced protein 1; nNOS, neuronal nitric oxide synthase; NT-3, neurotrophin-3; ROS, reactive oxygen species.