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. 2014 Jun 6;9:10. doi: 10.1186/1745-6150-9-10

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Copyright © 2014 Sorokina et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Orphan and non-orphan EC number distribution across superkingdoms. The green pie chart represents the proportion of orphan EC activities among all valid entries. Other pie charts represent the proportion of orphan activities among each superkingdom. An activity is considered as present in a superkingdom if at least one protein is annotated with corresponding EC number or the activity has been observed in an organism according to BRENDA database. The number and percentage of local and global orphans are given for each superkingdom. The small amount of characterized EC numbers in Archaea shows the obvious lack of knowledge about their metabolism.