Table 1. Vaccination cell dose and route of administration.
Autologous irradiated RCC vaccines with or without human GM-CSF gene transfer were administered at the assigned dose level; 50% of total dose was given intradermally and 50% s.c. to compare patient tolerability of the two routes of administration.
| Dose level | Autologous cell dose |
Intradermal injections |
Cell dose and volume | s.c. injections |
Cell dose and volume |
|---|---|---|---|---|---|
| 1 | 4 × 106 cells | 2 | 1 × 106 cells/0.5 cm3 | 2 | 1 × 106 cells/0.5 cm3 |
| 2 | 4 × 107 cells | 2 | 1 × 107 cells/0.5 cm3 | 2 | 1 × 107 cells/0.5 cm3 |
| 3 | 4 × 108 cells | 16 | 1.2 × 107 cells/0.6 cm3 | 5 | 4 × 107cells/2cm3 |