TABLE 2.
Lesion site | 18F-FDG |
64Cu-DOTA-trastuzumab*
|
|
---|---|---|---|
Day 1 | Day 2 | ||
All | 83 of 89 (93%) | 61 of 79 (77%)† | 54 of 61 (89%) |
Bone | 35 of 38 (92%) | 33 of 36 (92%) | 19 of 20 (95%) |
Lymph nodes | 30 of 31 (97%) | 20 of 31 (65%)‡,§ | 19 of 23 (88%) |
Liver | 8 of 10 (80%) | 1 of 3 (33%) | 8 of 8 (100%) |
Lung | 5 of 5 (100%) | 4 of 4 (100%) | 4 of 5 (80%) |
Pleural effusion | 2 of 2 (100%) | 0 of 2 (0%) | 1 of 2 (50%) |
Breast | 3 of 3 (100%) | 3 of 3 (100%) | 3 of 3 (100%) |
Combined data for 5 and 50 mg trastuzumab doses
P < 0.01 relative to 18F-FDG, all sites
P < 0.01 relative to 18F-FDG, lymph nodes
P < 0.05 relative to 64Cu-DOTA-trastuzumab Day 1, bone